Messi replaced Augusto Fernandez in the 61st minute, drawing a big ovation from a sea of No. 10 Argentina jerseys and the familiar colors of Barcelona, his club team. A few minutes later, the five-time FIFA Player of the Year got right back to work.
First, Roderick Miller's clearing attempt for Panama went off Gonzalo Higuain's hands as he went to protect his face and right to Messi, who took a couple dribbles and then beat Jaime Penedo on the ground to the goaltender's right side.
A left-footed chip past Penedo on the goalkeeper's right side finished off Messi's fourth international hat trick, joining friendlies against Switzerland and Brazil in 2012, and Guatemala in 2013