Playing for Melbourne Renegades, Gayle hit two humongous in a Big Bash League Twenty20 match against Brisbane Heat to achieve the landmark.
The left-handed Gayle, in his knock, also hit a couple of fours to take his tally of fours to 653, but is behind Australia's T20 star Brad Hodge, who leads the way with 664 fours to his name. New Zealand's Brendon McCullum is the third in the list with 605 fours.
Gayle is way ahead in terms of six hitting record with the next best being that of fellow West Indian all-rounder Kieron Pollard, who has hit 388 sixes. McCullum is on the third spot with 290 hits over the fence.